Marcel Kaiser Selected Research

African Trypanosomiasis (Nagana)

1/2021	Spirombandakamine A3 and Cyclombandakamines A8 and A9, Polycyclic Naphthylisoquinoline Dimers, with Antiprotozoal Activity, from a Congolese Ancistrocladus Plant.
1/2021	Enantiospecific antitrypanosomal in vitro activity of eflornithine.
2/2020	Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis.
1/2020	Activity of diphenyl ether benzyl amines against Human African Trypanosomiasis.
1/2020	In Vitro Drug Efficacy Testing Against Trypanosoma brucei.
9/2019	Targeting a Large Active Site: Structure-Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase.
12/2018	Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro.
11/2018	Complementary Quantitative Structure⁻Activity Relationship Models for the Antitrypanosomal Activity of Sesquiterpene Lactones.
1/2018	2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design.
1/2018	Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.

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Marcel Kaiser Research Topics

Disease

29	African Trypanosomiasis (Nagana) 01/2021 - 08/2007
27	Malaria 03/2022 - 09/2005
13	Chagas Disease (American Trypanosomiasis) 02/2020 - 11/2008
11	Infections 01/2021 - 05/2011
9	Neoplasms (Cancer) 01/2021 - 01/2011
8	Type 2 Diabetes Mellitus (MODY) 01/2021 - 06/2006
8	Neglected Diseases 01/2021 - 12/2010
5	Trypanosomiasis 11/2016 - 05/2010
4	Leishmaniasis 02/2020 - 03/2010
4	Parasitic Diseases (Parasitic Disease) 01/2020 - 04/2006
4	Leukemia 01/2018 - 12/2016
3	Parasitemia 01/2021 - 03/2013
3	Body Weight (Weight, Body) 01/2021 - 07/2011
3	Visceral Leishmaniasis (Kala Azar) 03/2019 - 01/2010
3	Communicable Diseases (Infectious Diseases) 08/2015 - 11/2010
3	Hypoglycemia (Reactive Hypoglycemia) 05/2014 - 08/2012
3	Weight Gain 10/2013 - 07/2011
2	Multiple Myeloma 11/2019 - 01/2017
2	Pancreatic Neoplasms (Pancreatic Cancer) 11/2018 - 10/2017
2	Tuberculosis (Tuberculoses) 05/2011 - 02/2010
1	Fever (Fevers) 03/2022
1	Mycetoma 06/2021
1	Hypertension (High Blood Pressure) 01/2021
1	Virus Diseases (Viral Diseases) 01/2021
1	Diabetic Neuropathies (Diabetic Neuropathy) 01/2021
1	Acidosis 01/2020
1	Fibrosarcoma 11/2019
1	Carcinoma (Carcinomatosis) 11/2019
1	Falciparum Malaria (Plasmodium falciparum Malaria) 02/2018
1	Dehydration (Water Stress) 10/2016
1	Seizures (Absence Seizure) 02/2016

Drug/Important Bio-Agent (IBA)

25	Pharmaceutical PreparationsIBA 06/2021 - 10/2010
7	Insulin (Novolin)FDA Link 11/2019 - 06/2006
7	Biological ProductsIBA 09/2015 - 05/2011
5	AlkaloidsIBA 06/2021 - 01/2017
4	Antimalarials (Antimalarial Agents)IBA 02/2016 - 09/2012
3	AminesIBA 01/2020 - 12/2011
3	fexinidazoleIBA 01/2020 - 12/2010
3	rhodesainIBA 01/2018 - 06/2013
3	Cysteine Proteases (Cysteine Protease)IBA 01/2018 - 06/2013
3	EnzymesIBA 09/2014 - 08/2007
3	Hypoglycemic Agents (Hypoglycemics)IBA 05/2014 - 08/2012
3	Insulin Detemir (Levemir)FDA Link 05/2014 - 05/2013
2	Eflornithine (Ornidyl)FDA Link 01/2021 - 02/2014
2	Antiparasitic Agents (Antiparasitics)IBA 01/2021 - 01/2019
2	PolyaminesIBA 01/2021 - 11/2013
2	Growth InhibitorsIBA 01/2020 - 12/2018
2	jozimine A2IBA 11/2019 - 10/2017
2	trypanothione reductaseIBA 09/2019 - 11/2008
2	LactonesIBA 11/2018 - 03/2014
2	SesquiterpenesIBA 11/2018 - 03/2014
2	NifurtimoxIBA 12/2016 - 02/2014
2	posaconazole FDA Link 12/2016 - 02/2015
2	SphingolipidsIBA 12/2015 - 02/2015
2	Chloroquine (Aralen)FDA LinkGeneric 04/2015 - 07/2010
2	Glucose (Dextrose)FDA LinkGeneric 05/2014 - 08/2012
2	cynaropicrinIBA 03/2014 - 11/2013
2	4-nitroimidazoleIBA 12/2011 - 12/2010
2	dUTP pyrophosphataseIBA 10/2011 - 02/2011
2	Anti-Bacterial Agents (Antibiotics)IBA 05/2011 - 09/2005
1	salicylanilideIBA 06/2021
1	Niclosamide FDA Link 06/2021
1	SalicylanilidesIBA 06/2021
1	PeroxidesIBA 06/2021
1	5- chloro- 2- hydroxy- N- (3- (trifluoromethyl)phenyl)benzamideIBA 06/2021
1	cycloartaneIBA 06/2021
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2021
1	semaglutideIBA 01/2021
1	ProteomeIBA 01/2021
1	QuinazolinesIBA 01/2021
1	empagliflozinIBA 01/2021
1	Dihydrotachysterol (AT 10)IBA 01/2021
1	Glucagon-Like Peptide-1 Receptor AgonistsIBA 01/2021
1	Sitagliptin Phosphate (Januvia)FDA Link 01/2021
1	Liraglutide FDA Link 01/2021
1	Proteasome InhibitorsIBA 02/2020
1	phenyl etherIBA 01/2020
1	MethacrylatesIBA 03/2019
1	Primaquine FDA Link 02/2018
1	TriazolesIBA 01/2018
1	cruzipainIBA 01/2018
1	falcipain 2IBA 01/2018
1	Ether (Diethyl Ether)IBA 01/2018
1	ancistrobenomine BIBA 09/2017
1	SteroidsIBA 07/2017
1	Melphalan (Alkeran)FDA LinkGeneric 01/2017
1	P 11 (P-11)IBA 01/2017
1	dioncophylline AIBA 01/2017
1	ancistectorine DIBA 12/2016
1	14-alpha Demethylase InhibitorsIBA 12/2016
1	benzonidazole (benznidazole)IBA 12/2016
1	AcetamidesIBA 11/2016
1	diphenyl (biphenyl)IBA 11/2016
1	siphonazoleIBA 10/2016
1	NucleotidesIBA 01/2016

Therapy/Procedure

10	Therapeutics 01/2021 - 06/2006
4	Traditional Medicine (Folk Remedies) 03/2022 - 03/2010
3	Drug Therapy (Chemotherapy) 01/2020 - 02/2010
3	Glycemic Control 05/2013 - 07/2011
1	Self Medication 01/2020